What is Ductal Carcinoma In Situ (DCIS) and Lobular Carcinoma In Situ (LCIS)?

  • Ductal carcinoma in situ (DCIS):
    • Is a noninvasive carcinoma of the breast
    • It is defined as the proliferation of malignant epithelial cells:
      • Confined to the mammary ducts and without evidence of invasion through the basement membrane
    • Because it is noninvasive:
      • DCIS does not pose a risk of metastasis
  • Lobular carcinoma in situ (LCIS):
    • Was previously considered a form of noninvasive carcinoma:
      • But is now understood to be a benign entity that is a pathologic marker of increased breast cancer risk:
        • In either breast
    • Atypical lobular hyperplasia (ALH) and LCIS:
      • Are both forms of lobular neoplasia and, together with atypical ductal hyperplasia (ADH):
        • Represent proliferative nonmalignant breast lesions

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