Primary Hyperparathyroidism Epidemiology

  • Primary Hyperparathyroidism (PHPT):
    • Is a common disorder:
      • Affecting 100,000 individuals annually in the United States
    • PHPT occurs in 0.1% to 0.3% of the general population
    • Is more common in women (1:500) than in men (1:2000)
    • Increased PTH production leads to hypercalcemia via:
      • Increased GI absorption of calcium, increased production of vitamin D3, and reduced renal calcium clearance
    • PHPT is characterized by increased parathyroid cell proliferation and PTH secretion:
      • That is independent of calcium levels

Leave a comment