Chest Wall Recurrence after Mastectomy – Calor Trial

  • Patients with chest wall recurrence:
    • Are at high risk for:
      • Concurrent systemic recurrences:
        • Therefore, obtaining systemic staging and receptor information on the recurrence should be the first consideration
  • Often, there may be extensive local regional involvement in several areas along the chest wall and in the nodal regions
  • According to National Comprehensive Cancer Network guidelines:
    • Systemic staging generally consists of either a PET/CT scan or a CT of the chest, abdomen, and pelvis, as well as a bone scan
  • Surgical excision with negative margins:
    • Followed by comprehensive chest wall and nodal radiotherapy may be indicated in the absence of widespread systemic disease
  • These patients should be managed by a multidisciplinary team, including:
    • The surgical oncologist, medical oncologists, radiologists, pathologists, and potentially a plastic surgeon
  • Patients may or may not benefit from chemotherapy:
    • In the CALOR trial:
      • Chemotherapy was found to benefit patients with resected ER negative isolated locoregional recurrence:
        • But not ER positive isolated local regional recurrence
  • References

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