Melanoma Margins Trial II (MelMarT-II)

Rodrigo Arrangoiz MS, MD, FACS, FSSO
  • The Melanoma Margins Trial II (MelMarT-II):
    • Is a pivotal phase III, multicenter, randomized controlled trial:
      • Designed to evaluate the safety and efficacy of narrower surgical margins:
        • For primary cutaneous melanomas that are stage T2b or higher
    • This trial specifically compares 1-cm margins with the standard 2-cm margins:
      • To determine if the narrower margin can provide equivalent outcomes in terms of local control and survival
    • The trial includes patients with primary melanomas thicker than 2 mm (T2b or higher):
      • It aims to assess whether a 1-cm margin can achieve similar rates of local recurrence, disease-free survival, and overall survival compared to the traditional 2-cm margin
    • The rationale for this study:
      • Is based on the hypothesis that narrower margins may reduce surgical morbidity and improve cosmetic outcomes without compromising oncologic safety
  • The MelMarT-II trial:
    • Is significant because it addresses the ongoing debate about the optimal surgical margin for thicker melanomas
  • Previous studies have established that a 2-cm margin is safe for melanomas thicker than 2 mm:
    • But the potential benefits of a 1-cm margin in terms of reduced morbidity and improved quality of life warrant further investigation
  • References:
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Published by Rodrigo Arrangoiz MS, MD, FACS, FSSO

My name is Rodrigo Arrangoiz I am a breast surgeon/ thyroid surgeon / parathyroid surgeon / head and neck surgeon / surgical oncologist that works at Center for Advanced Surgical Oncology in Miami, Florida. I was trained as a surgeon at Michigan State University from (2005 to 2010) where I was a chief resident in 2010. My surgical oncology and head and neck training was performed at the Fox Chase Cancer Center in Philadelphia from 2010 to 2012. At the same time I underwent a masters in science (Clinical research for health professionals) at the University of Drexel. Through the International Federation of Head and Neck Societies / Memorial Sloan Kettering Cancer Center I performed a two year head and neck surgery and oncology / endocrine fellowship that ended in 2016. Mi nombre es Rodrigo Arrangoiz, soy cirujano oncólogo / cirujano de tumores de cabeza y cuello / cirujano endocrino que trabaja Center for Advanced Surgical Oncology en Miami, Florida. Fui entrenado como cirujano en Michigan State University (2005 a 2010 ) donde fui jefe de residentes en 2010. Mi formación en oncología quirúrgica y e n tumores de cabeza y cuello se realizó en el Fox Chase Cancer Center en Filadelfia de 2010 a 2012. Al mismo tiempo, me sometí a una maestría en ciencias (investigación clínica para profesionales de la salud) en la Universidad de Drexel. A través de la Federación Internacional de Sociedades de Cabeza y Cuello / Memorial Sloan Kettering Cancer Center realicé una sub especialidad en cirugía de cabeza y cuello / cirugia endocrina de dos años que terminó en 2016.

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