Primary Breast Lymphoma

Rodrigo Arrangoiz MS, MD, FACS, FSSO
  • Current management strategies for primary breast lymphoma:
    • Are largely based on results published in small, single-institution series
  • Historically, primary breast lymphoma was treated with:
    • Modified radical mastectomy with or without adjuvant chemotherapy or radiotherapy
  • Treatment strategies had focused on:
    • Anthracycline-based chemotherapy with or without consolidative radiotherapy
  • Current treatment guidelines dictate that surgery should be reserved for obtaining adequate tissue for diagnosis, if needed, and should not be regarded as a therapeutic modality in the treatment of this disease:
    • In several series, surgery has been associated with worse outcomes
  • Some histologies may be amenable to localized surgery so understanding the disease pathology is important in decision making
  • While axillary nodal status is an important prognosticator:
    • There are no definitive guidelines regarding how to stage the axilla:
      • In addition to CT scan, axillary ultrasound with percutaneous biopsy is frequently used
    • Sentinel lymph node biopsy has not been studied in this malignancy and currently has no role in its workup
  • References:
    • Aviles A, Delgado S, Nambo MJ, Neri N, Murillo E, Cleto S. Primary breast lymphoma: results of a controlled clinical trial. Oncology. 2005;69(3):256-260.
    • Aviv A, Tadmor T, Polliack A. Primary diffuse large B-cell lymphoma of the breast: looking at pathogenesis, clinical issues and therapeutic options. Ann Oncol. 2013;24(9):2236-2244.
    • el-Ghazawy IM, Singletary SE. Surgical management of primary lymphoma of the breast. Ann Surg. 1991;214(6):724-726.
    • Jennings WC, Baker RS, Murray SS, et al. Primary breast lymphoma: the role of mastectomy and the importance of lymph node status. Ann Surg. 2007;245(5):784-789.
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Published by Rodrigo Arrangoiz MS, MD, FACS, FSSO

My name is Rodrigo Arrangoiz I am a breast surgeon/ thyroid surgeon / parathyroid surgeon / head and neck surgeon / surgical oncologist that works at Center for Advanced Surgical Oncology in Miami, Florida. I was trained as a surgeon at Michigan State University from (2005 to 2010) where I was a chief resident in 2010. My surgical oncology and head and neck training was performed at the Fox Chase Cancer Center in Philadelphia from 2010 to 2012. At the same time I underwent a masters in science (Clinical research for health professionals) at the University of Drexel. Through the International Federation of Head and Neck Societies / Memorial Sloan Kettering Cancer Center I performed a two year head and neck surgery and oncology / endocrine fellowship that ended in 2016. Mi nombre es Rodrigo Arrangoiz, soy cirujano oncólogo / cirujano de tumores de cabeza y cuello / cirujano endocrino que trabaja Center for Advanced Surgical Oncology en Miami, Florida. Fui entrenado como cirujano en Michigan State University (2005 a 2010 ) donde fui jefe de residentes en 2010. Mi formación en oncología quirúrgica y e n tumores de cabeza y cuello se realizó en el Fox Chase Cancer Center en Filadelfia de 2010 a 2012. Al mismo tiempo, me sometí a una maestría en ciencias (investigación clínica para profesionales de la salud) en la Universidad de Drexel. A través de la Federación Internacional de Sociedades de Cabeza y Cuello / Memorial Sloan Kettering Cancer Center realicé una sub especialidad en cirugía de cabeza y cuello / cirugia endocrina de dos años que terminó en 2016.

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