Recommendations for the use of Contralateral Mastectomy (CM) in patients with Unilateral Breast Cancer

  • Contralateral mastectomy (CM) can be considered in:
    • Patients who have a high risk of contralateral breast cancer:
      • Due to:
        • A germline mutation
        • Prior chest irradiation
        • Strong family history
  • CM is contraindicated in:
    • Patients with comorbidities in whom the increased risk of surgical complications and / or the longer time under general anesthesia may be detrimental to their health
  • CM should be discouraged in:
    • Patients with metastatic disease:
      • Even if a palliative unilateral mastectomy is being considered
    • Patients with oligometastatic disease in whom a unilateral mastectomy, as recommended by a multidisciplinary care team or as part of a clinical trial:
      • Is being performed for curative intent
    • Patients with locally advanced breast cancer or inflammatory breast cancer:
      • For whom the expeditious delivery of adjuvant therapy may impact outcomes
    • Patients whose main reason for choosing CM is improving survival or decreasing the risk of a recurrence of their index cancer:
      • Despite proper counseling
    • Patients with a significant competing risk of mortality secondary to their breast cancer, other malignancies, or comorbidities

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