Elective Surgical versus Radiation Therapy Treatment in Head and Neck Cancer

  • The efficacy of elective nodal irradiation (ENI) versus elective neck dissection:
    • Showed no obvious differences:
      • As reported by Barkley in a major retrospective experience of neck management in 596 patients with oropharynx, larynx, or hypopharynx carcinoma treated at MD Anderson Cancer Center:
        • Two hundred thirteen were oropharynx, 202 larynx, and 181 hypopharynx
        • Of these, 226 were N0 whereas 370 were node positive
        • Patients underwent radiation therapy (n = 292), surgical management (n = 199), or combined modality therapy (n = 105) of the neck
        • All patients had a minimum follow-up of 2 years and a median follow-up of 4 years
        • Among the electively treated patients:
        • Regional control was greater than 90% regardless of the treatment approach as long as comprehensive neck treatment was implemented
        • However, partial treatment of the neck resulted in 15%, 35%, and 20% regional failure after radiation, surgery, or combined therapy, respectively

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