Work-up of Breast Implant-Associated Anaplastic Large Cel Lymphoma

Rodrigo Arrangoiz MS, MD, FACS, FSSO
  • Breast implant-associated anaplastic large cell lymphoma (BIA-ALCL):
    • Is an uncommon lymphoma that has only been reported in patients with a history of a textured breast implant device
  • Suggested theories of the cause of BIA-ALCL include:
    • Textured implant particulate
    • Chronic allergic inflammation, and / or response to a biofilm
  • Following National Comprehensive Cancer Network (NCCN) guidelines:
    • A swollen breast can be evaluated with ultrasound for either a:
      • Fluid collection
      • Capsular mass
      • Lymph node swelling
    • Fluid collections should be aspirated percutaneously:
      • A minimum of 20 ml but ideally as much fluid available should be sent for:
        • CD30 immunohistochemistry
        • Cell block cytology and flow cytometry evaluation and labeled to “rule out BIA-ALCL
      • CD30 testing is critical to direct pathologists
      • Efforts should be made to establish a diagnosis:
        • Prior to any surgical intervention
  • References
  • Brody GS, Deapen D, Taylor CR, Pinter-Brown L, House-Lightner SR, Andersen JS, et al. Anaplastic large cell lymphoma occurring in women with breast implants: analysis of 173 cases. Plast Reconstr Surg. 2015;135(3);695-705.
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Published by Rodrigo Arrangoiz MS, MD, FACS, FSSO

My name is Rodrigo Arrangoiz I am a breast surgeon/ thyroid surgeon / parathyroid surgeon / head and neck surgeon / surgical oncologist that works at Center for Advanced Surgical Oncology in Miami, Florida. I was trained as a surgeon at Michigan State University from (2005 to 2010) where I was a chief resident in 2010. My surgical oncology and head and neck training was performed at the Fox Chase Cancer Center in Philadelphia from 2010 to 2012. At the same time I underwent a masters in science (Clinical research for health professionals) at the University of Drexel. Through the International Federation of Head and Neck Societies / Memorial Sloan Kettering Cancer Center I performed a two year head and neck surgery and oncology / endocrine fellowship that ended in 2016. Mi nombre es Rodrigo Arrangoiz, soy cirujano oncólogo / cirujano de tumores de cabeza y cuello / cirujano endocrino que trabaja Center for Advanced Surgical Oncology en Miami, Florida. Fui entrenado como cirujano en Michigan State University (2005 a 2010 ) donde fui jefe de residentes en 2010. Mi formación en oncología quirúrgica y e n tumores de cabeza y cuello se realizó en el Fox Chase Cancer Center en Filadelfia de 2010 a 2012. Al mismo tiempo, me sometí a una maestría en ciencias (investigación clínica para profesionales de la salud) en la Universidad de Drexel. A través de la Federación Internacional de Sociedades de Cabeza y Cuello / Memorial Sloan Kettering Cancer Center realicé una sub especialidad en cirugía de cabeza y cuello / cirugia endocrina de dos años que terminó en 2016.

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