Radiation Changes in the Breast Seen on Mammogram

Right craniocaudad image.
Right mediolateral oblique image.
  • The mammogram:
    • Shows trabecular thickening and an increased thickness of the skin
  • Trabecular thickening:
    • Is an increased prominence of linear structures in the breast:
      • Primarily corresponding to Cooper’s ligaments
    • It is almost always seen in conjunction with skin thickening:
      • It indicates significant breast edema
    • It has a number of different causes, including:
      • Congestive heart failure
      • Renal failure
      • Venous or lymphatic obstruction
      • Diffusely infiltrating carcinoma
      • Radiation
    • When the cause is lymphatic obstruction:
      • The obstruction can be the result of surgery, radiation, or lymphatic invasion by cancer
  • Unilateral breast edema with increased trabecular and skin thickening:
    • Sometimes occurs with congestive heart failure
  • The pedal edema that develops during the daytime:
    • Decreases at night and the fluid accumulates in the dependent breast in patients who sleep on their side
  • References
    • Berg, WA, Birdwell RL, Kennedy A. Diagnostic Imaging: Breast. Salt Lake City, UT: Amirsys; 2006.
    • Verbelen H, Gebruers N, Beyers T, De Monie AC, Tjalma W. Breast edema in breast cancer patients following breast-conserving surgery and radiotherapy: a systematic review. Breast Cancer Res Treat. 2014;147(3):463-471.
    • Wratten CR, O’Brien PC, Hamilton CS, Bill D, Kilmurray J, Denham JW. Breast edema in patients undergoing breast-conserving treatment for breast cancer: assessment via high frequency ultrasound. Breast J. 2007;13(3):266-273.
    • Menta A, Fouad TM, Lucci A, Le-Petross H, Stauder MC, Woodward WA, et al. Inflammatory breast cancer: what to know about this unique, aggressive breast cancer. Surg Clin North Am. 2018;98(4):787-800.
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