Phyllodes Tumors

  • Introduction
    • Phyllodes tumors (PTs) of the breast are considered a rare fibroepithelial neoplasms of the breast and are considered a challenging for both pathologists and surgeons
    • The World Health Organization (WHO) has classified PTs histologically as:
      • Benign
      • Borderline
      • Malignant
    • PTs can be detected in all ages:
      • However, the median age of presentation is 45 years
    • PTs can mimic fibroadenoma in clinical presentations
    • Breast imaging is also similar to fibroadenomas
    • Cytological diagnosis of PTs by biopsy is usually unreliable:
      • However, a core needle biopsy is superior to fine-needle aspiration
    • Surgery is considered the mainstay treatment for PTs of the breast:
      • With a goal of achieving negative margins
    • Adjuvant chemotherapy and radiation therapy use for malignant PTs are controversial

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