Male Breast Cancer Risk Factors

Rodrigo Arrangoiz MS, MD, FACS, FSSO

Top 10 Risk factors for MALE Breast Cancer

  1. Aging

Risk increases with age. On average, men with breast cancer are about 72 years old when they are diagnosed.

  1. Family history of breast cancer

About 1 out of 5 men with breast cancer have a close relative, male or female, with the disease.

  1. Inherited gene mutations

Men with a BRCA2 gene mutation have an increased risk of breast cancer, with a lifetime risk of about 6 in 100. BRCA1 mutations can also cause breast cancer in men, but the risk is lower, about 1 in 100 ( in women BRCA1 has higher risk). Mutations in CHEK2, PTEN and PALB2 genes might also be responsible for some breast cancers in men.

  1. Klinefelter syndrome

XXY : Men with Klinefelter syndrome (1 in 1000) have lower levels of androgens and more estrogens, have gynecomastia.
Increases breast cancer risk 20 – 60 times the risk of a man in the general population.

  1. Radiation exposure

Prior chest radiation treatment for lymphoma has an increased risk of developing breast cancer.

  1. Alcohol

Heavy drinking ⬆️ risk likely due to its effects on the liver.

  1. Liver disease

Cirrhosis lower levels of androgens and higher levels of estrogen. Also higher chance of developing gynecomastia.

  1. Estrogen treatment

Estrogen-related drugs were once used in hormonal therapy for men with prostate cancer. Transgender/transsexual individuals who take high doses of estrogens as part of sex reassignment could also have a higher breast cancer risk. Not much published data yet.

  1. Obesity

Fat cells in the body convert androgens to estrogens. Obese men have ⬆️ levels of estrogens in their body.

  1. Testicular conditions

Certain conditions, such as having an undescended testicle, mumps as an adult, or history of orchiectomy may increase male breast cancer risk.

https://amp.cancer.org/cancer/breast-cancer-in-men/about/key-statistics.html

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Published by Rodrigo Arrangoiz MS, MD, FACS, FSSO

My name is Rodrigo Arrangoiz I am a breast surgeon/ thyroid surgeon / parathyroid surgeon / head and neck surgeon / surgical oncologist that works at Center for Advanced Surgical Oncology in Miami, Florida. I was trained as a surgeon at Michigan State University from (2005 to 2010) where I was a chief resident in 2010. My surgical oncology and head and neck training was performed at the Fox Chase Cancer Center in Philadelphia from 2010 to 2012. At the same time I underwent a masters in science (Clinical research for health professionals) at the University of Drexel. Through the International Federation of Head and Neck Societies / Memorial Sloan Kettering Cancer Center I performed a two year head and neck surgery and oncology / endocrine fellowship that ended in 2016. Mi nombre es Rodrigo Arrangoiz, soy cirujano oncólogo / cirujano de tumores de cabeza y cuello / cirujano endocrino que trabaja Center for Advanced Surgical Oncology en Miami, Florida. Fui entrenado como cirujano en Michigan State University (2005 a 2010 ) donde fui jefe de residentes en 2010. Mi formación en oncología quirúrgica y e n tumores de cabeza y cuello se realizó en el Fox Chase Cancer Center en Filadelfia de 2010 a 2012. Al mismo tiempo, me sometí a una maestría en ciencias (investigación clínica para profesionales de la salud) en la Universidad de Drexel. A través de la Federación Internacional de Sociedades de Cabeza y Cuello / Memorial Sloan Kettering Cancer Center realicé una sub especialidad en cirugía de cabeza y cuello / cirugia endocrina de dos años que terminó en 2016.

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