Sentinel Lymph Node Biopsy in Multicentric / Multifocal Breast Tumors

  • Patients with multiple ipsilateral breast cancers:
    • Were excluded from the initial trials of SLNB
  • A systematic review evaluated the accuracy of SLNB in multifocal and multicentric tumors:
    • This review reported:
      • Significantly higher rates of lymph node metastases
      • Higher rates of involved nonsentinel lymph nodes:
        • In patients with multifocal tumors than patients with unifocal primary tumors
  • In several studies:
    • There is no significant difference in the false negative rate or failed localizations for patients with multifocal tumors
  • In a prospective study:
    • 30 patients with multifocal tumors underwent SLNB followed by ALND:
      • In 30 of 30 patients, the sentinel lymph node was identified and the false negative rate was 0%:
        • Supporting the use of SLNB for patients with multifocal tumors

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