Breast Nodules on Ultrasound

Targeted ultrasound of mammographic abnormality
  • At first glance, the rounded, almost anechoic sonographic mass could be mistaken for a simple cyst:
    • However, closer inspection shows some small spiculations, angular margins, and a suggestion of an echogenic halo
      • These findings alone make it a BIRADS 4 lesion
    • Even if they were not present:
      • The lesion is rounded and, therefore, does not meet any of the 3 benign definitions:
        • That would allow it to be classified BIRADS 3
    • Although the lesion is small, homogeneous, and does not cause worrisome posterior acoustical artifacts:
      • Cancers this small frequently have no shadowing or enhancement
    • It could be benign:
      • But it has the appearance that a high-grade carcinoma would have when it is less than a centimeter in diameter
  • When a nodule seen on mammogram and ultrasound are in the same location, have the same size and shape, and the same surrounding tissue:
    • They can be confidently assumed to be the same
  • If it were going to be followed, mammograms would expose this young woman to ionizing radiation and thus a small but real risk of developing a radiation-induced malignancy:
    • So a 6-month follow-up ultrasound would be the modality of choice
  • Because the lesion cannot be confidently considered to be less than BIRADS 4a:
    • Evaluation with a needle is required:
      • It is possible aspiration would collapse a small cyst:
        • If not, percutaneous biopsy should be done with a spring-loaded, vacuum-assisted, or intact-removal device, depending on the experience and expertise of the surgeon
  • Steps in the evaluation of breast nodules by ultrasound:
    • You first evaluate the lesion for any of the 10 malignant signs:
      • Shadowing
      • Hypoechoic echotexture
      • Spiculation
      • Angular margins
      • Thick echogenic halo
      • Microlobulation
      • Taller than wide
      • Duct extension
      • Branching pattern
      • Calcifications)
    • Finding none:
      • You move on to the second step in the evaluation process and specifically look for one of the three strictly defined benign signs:
        • If any of them are found:
          • The lesion can be considered BIRADS 3:
            • The three benign findings defined by Stavros are:
              • A purely hyperechoic lesion with no hypoechoic area larger than a normal duct or lobule
              • Elliptical, wider than tall, well-circumscribed and thin echogenic capsule
              • Gently lobulated, wider than tall, well-circumscribed and thin echogenic capsule
          • Combining the elliptical or gently lobulated shapes with the presence of a complete, thin echogenic capsule:
            • Is necessary because many circumscribed carcinomas and most ductal carcinoma in situ are encompassed in a thin, echogenic capsule:
              • However, the shape of circumscribed invasive carcinoma or pure ductal carcinoma in situ:
              • Is rarely elliptical or gently lobulated
      • Because this lesion is elliptical, wider-than-tall, well-circumscribed, and has a thin, echogenic capsule:
        • It is BIRADS 3:
          • A 6-month follow-up ultrasound would be appropriate unless the anxiety of the patient makes core biopsy a better option
  • References
    • D’Orsi CJ, Sickles EA, Mendelson EB, Morris EA. ACR BI-RADS® Atlas, Breast Imaging Reporting and Data System, 5th ed. Reston, VA, American College of Radiology, 2013.
    • Madjar H, Mendelson EB. The Practice of Breast Ultrasound. 2nd ed. Thieme; 2008;141-144.
    • Stavros AT. Breast Ultrasound. Philadelphia, PA: Lippincott Williams & Wilkins; 2004.
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