• Patients with non-palpable breast cancers require localization procedures (either with wires or other devices):
  • To assist surgeons performing breast-conserving surgery
  • Documentation of removal:
    • Is considered the standard of care regardless of the method of localization:
      • This documentation can be accomplished with specimen mammography and / or intraoperative ultrasound
  • Compression of the specimen:
    • Does not result in improved accuracy of detection, and leads to reduction in specimen volume and dimensions:
      • This can result in the “pancake phenomenon”:
        • In which flattening of the specimen leads to the presence of ink within the crevices of the specimen:
          • Resulting in positive margins
        • This phenomenon is independent of age of the patient, breast density, and type of lesion (mass vs calcifications)
  • Reviews comparing accuracy of the specimen mammogram:
    • To predict the presence of negative margins have shown poor results:
      • 32% negative predictive value:
        • However, tumor extending to the edge of the specimen on mammogram does correlate with histologic margins:
          • With 98% predictive value
  • References
    • Performance and practice guidelines for breast-conserving surgery/partial mastectomy. American Society of Breast Surgeons. Version 2.2015. https://www.breastsurgeons.org/statements/guidelines/PerformancePracticeGuidelines_Breast-ConservingSurgery-PartialMastectomy.pdf. Accessed September 19, 2019.
    • Mendez, JE, ter Meulen D, Padussis J, et al. Tissue compression is not necessary for needle-localized lesion identification. Amer J Surg. 2005;190(4):580-582.
    • Graham RA, Homer MJ, Katz J, Rothschild J, Safaii H, Supran S. The pancake phenomenon contributes to the inaccuracy of margin assessment in patients with breast cancer. Am J Surg. 2002;184(2):89-93.
    • Graham RA, Homer MJ, Sigler CJ et al. The efficacy of specimen radiography in evaluating the surgical margins of impalpable breast carcinoma. AJR Am J Roentgenol. 1994;162(1):33-36.
#Arrangoiz #BreastSurgen #CancerSurgeon

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