MonarchE Trial In High Risk Breast Cancer II

Rodrigo Arrangoiz MS, MD, FACS, FSSO
  • Based on initial results from the monarchE trial:
    • The FDA approved abemaciclib plus endocrine therapy (tamoxifen or an aromatase inhibitor) for adjuvant treatment of:
      • Hormone receptor–positive
      • HER2-negative (HER2-)
      • Node-positive
      • Early breast cancer in patients at high risk of recurrence and with a Ki-67 score of 20% or higher (as determined by an FDA-approved test)
  • This marked the first approval of a CDK4/6 inhibitor:
    • For use as adjuvant treatment of breast cancer
  • The limitation of the indication to a Ki-67 score of at least 20% has generated some confusion and controversy in the field:
    • Especially in light of the subsequent guidance from the American Society of Clinical Oncology and the National Comprehensive Cancer Network:
      • Which both recommend patient selection for adjuvant abemaciclib plus endocrine therapy in accordance with the trial design
#Arrangoiz #BreastSurgeon #CancerSurgeon #SurgicalOncologist #MountSinaiMedicalCenter #MSCM #Miami #Mexico #BreastCancer

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Published by Rodrigo Arrangoiz MS, MD, FACS, FSSO

My name is Rodrigo Arrangoiz I am a breast surgeon/ thyroid surgeon / parathyroid surgeon / head and neck surgeon / surgical oncologist that works at Center for Advanced Surgical Oncology in Miami, Florida. I was trained as a surgeon at Michigan State University from (2005 to 2010) where I was a chief resident in 2010. My surgical oncology and head and neck training was performed at the Fox Chase Cancer Center in Philadelphia from 2010 to 2012. At the same time I underwent a masters in science (Clinical research for health professionals) at the University of Drexel. Through the International Federation of Head and Neck Societies / Memorial Sloan Kettering Cancer Center I performed a two year head and neck surgery and oncology / endocrine fellowship that ended in 2016. Mi nombre es Rodrigo Arrangoiz, soy cirujano oncólogo / cirujano de tumores de cabeza y cuello / cirujano endocrino que trabaja Center for Advanced Surgical Oncology en Miami, Florida. Fui entrenado como cirujano en Michigan State University (2005 a 2010 ) donde fui jefe de residentes en 2010. Mi formación en oncología quirúrgica y e n tumores de cabeza y cuello se realizó en el Fox Chase Cancer Center en Filadelfia de 2010 a 2012. Al mismo tiempo, me sometí a una maestría en ciencias (investigación clínica para profesionales de la salud) en la Universidad de Drexel. A través de la Federación Internacional de Sociedades de Cabeza y Cuello / Memorial Sloan Kettering Cancer Center realicé una sub especialidad en cirugía de cabeza y cuello / cirugia endocrina de dos años que terminó en 2016.

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