MonarchE Trial In High Risk Early Breast Cancer III

Rodrigo Arrangoiz MS, MD, FACS, FSSO
  • At updated analysis, the safety findings were consistent with what had been reported previously:
    • Adverse events (AEs) associated with adjuvant abemaciclib are considered manageable and acceptable in this patient population
  • The most common AEs reported (≥ 20%) in the abemaciclib plus endocrine therapy arm and at least 2% higher than in the endocrine therapy–alone arm were:
    • Diarrhea, infections, neutropenia, fatigue, leukopenia, nausea, anemia, and headache
    • The most frequently reported (≥ 5%) grade 3 or 4 AEs were:
      • Neutropenia, leukopenia, diarrhea, and lymphopenia
    • Clinicians should be aware of the potential for certain rare, but serious, toxicities:
      • Venous thromboembolism
      • Interstitial lung disease / pneumonitis
#Arrangoiz #BreastSurgeon #CancerSurgeon #SurgicalOncologist #MountSinaiMedicalCenter #MSCM #Miami #Mexico #BreastCancer
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Published by Rodrigo Arrangoiz MS, MD, FACS, FSSO

My name is Rodrigo Arrangoiz I am a breast surgeon/ thyroid surgeon / parathyroid surgeon / head and neck surgeon / surgical oncologist that works at Center for Advanced Surgical Oncology in Miami, Florida. I was trained as a surgeon at Michigan State University from (2005 to 2010) where I was a chief resident in 2010. My surgical oncology and head and neck training was performed at the Fox Chase Cancer Center in Philadelphia from 2010 to 2012. At the same time I underwent a masters in science (Clinical research for health professionals) at the University of Drexel. Through the International Federation of Head and Neck Societies / Memorial Sloan Kettering Cancer Center I performed a two year head and neck surgery and oncology / endocrine fellowship that ended in 2016. Mi nombre es Rodrigo Arrangoiz, soy cirujano oncólogo / cirujano de tumores de cabeza y cuello / cirujano endocrino que trabaja Center for Advanced Surgical Oncology en Miami, Florida. Fui entrenado como cirujano en Michigan State University (2005 a 2010 ) donde fui jefe de residentes en 2010. Mi formación en oncología quirúrgica y e n tumores de cabeza y cuello se realizó en el Fox Chase Cancer Center en Filadelfia de 2010 a 2012. Al mismo tiempo, me sometí a una maestría en ciencias (investigación clínica para profesionales de la salud) en la Universidad de Drexel. A través de la Federación Internacional de Sociedades de Cabeza y Cuello / Memorial Sloan Kettering Cancer Center realicé una sub especialidad en cirugía de cabeza y cuello / cirugia endocrina de dos años que terminó en 2016.

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