Primary Lymphoma of the Breast

Rodrigo Arrangoiz MS, MD, FACS, FSSO
👉Primary lymphoma of the breast is a rare, non-epithelial neoplasm that represents less than 0.5% of breast malignancies.
👉It most commonly presents in women over the age of 40 years.
👉Though a variety of histologic types may be seen, most primary breast lymphomas are non-Hodgkin lymphomas of the diffuse large B-cell type.
👉There has been a recent association between breast implants and anaplastic large cell lymphoma, a T-cell lymphoma subtype.
👉About 10% of patients will report constitutional B symptoms (ie, fever, night sweats, weight loss).
👉Wiseman and Liao described four criteria defining primary breast lymphomas in 1972:
👉All of the following must be met for this diagnosis:
👉First, the breast is the clinical site of presentation.
👉Second, there is no history of lymphoma or evidence of widespread disease.
👉Third, there is lymphoma in close association with breast parenchyma on pathologic evaluation.
👉Fourth, ipsilateral nodal involvement, if present, developed simultaneously with the breast tumor.
👉Lymphomas of the breast that do not meet these criteria qualify as secondary tumors.
👉Primary breast lymphoma is either stage IE—localized to the breast or stage IIE—involving both the breast and the ipsilateral axillary lymph nodes.
👉Concurrent axillary nodal involvement is seen in about 30% of patients. 

Rodrigo Arrangoiz MS, MD, FACScirujano oncology y miembro de Sociedad Quirúrgica S.C en el America British Cowdray Medical Center en la ciudad de Mexico:

  • Es experto en el manejo del cáncer de mama.

Training:

• General surgery:

• Michigan State University:

• 2004 al 2010

• Surgical Oncology / Head and Neck Surgery / Endocrine Surgery:

• Fox Chase Cancer Center (Filadelfia):

• 2010 al 2012

• Masters in Science (Clinical research for health professionals):

• Drexel University (Filadelfia):

• 2010 al 2012

• Surgical Oncology / Head and Neck Surgery / Endocrine Surgery:

• IFHNOS / Memorial Sloan Kettering Cancer Center:

• 2014 al 2016

#Arrangoiz

#Surgeon

#Cirujano

#SurgicalOncologist

#CirujanoOncologo

#BreastSurgeon

#CirujanodeMama

#CancerSurgeon

#CirujanodeCancer

REFERENCES

  1. Aviles A, Delgado S, Nambo MJ, Neri N, Murillo E, Cleto S. Primary breast lymphoma: results of a controlled clinical trial. Oncology. 2005;69:256-260. [PubMed: 16166814]. http://www.ncbi.nlm.nih.gov/pubmed/16166814
  2. Aviv A, Tadmor T, Polliack A. Primary diffuse large B-cell lymphoma of the breast: looking at pathogenesis, clinical issues and therapeutic options. Ann Oncol. 2013;24:2236-2244. [PubMed: 23712546]. http://www.ncbi.nlm.nih.gov/pubmed/?term=23712546
  3. el-Ghazawy IM, Singletary SE. Surgical management of primary lymphoma of the breast. Ann Surg. 1991;214:724-726. [PubMed: 1741653]. http://www.ncbi.nlm.nih.gov/pubmed/?term=1741653
  4. Jennings WC, Baker RS, Murray SS, et al. Primary breast lymphoma: the role of mastectomy and the importance of lymph node status. Ann Surg. 2007;245:784-789. [PubMed: 17457172] http://www.ncbi.nlm.nih.gov/pubmed/?term=17457172
  5. Miranda RN, Aladily TN, Prince HM, et al. Breast implant-associated anaplastic large-cell lymphoma: long-term follow-up of 60 patients. J Clin Oncol. 2013;32:114-120. [PubMed: 25254804]. https://www.ncbi.nlm.nih.gov/pubmed/24323027
  6. Ryan G, Martinelli G, Kuper-Hommel M, et al; International Extranodal Lymphoma Study Group. Primary diffuse large B-cell lymphoma of the breast: prognostic factors and outcomes of a study by the International Extranodal Lymphoma Study Group. Ann Oncol. 2008;19:233-241. [PubMed: 17932394]. https://www.ncbi.nlm.nih.gov/pubmed/17932394
  7. Wiseman C, Liao KT. Primary lymphoma of the breast. Cancer. 1972;29:1705-1712. [PubMed: 4555557]. http://www.ncbi.nlm.nih.gov/pubmed/4555557
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Published by Rodrigo Arrangoiz MS, MD, FACS, FSSO

My name is Rodrigo Arrangoiz I am a breast surgeon/ thyroid surgeon / parathyroid surgeon / head and neck surgeon / surgical oncologist that works at Center for Advanced Surgical Oncology in Miami, Florida. I was trained as a surgeon at Michigan State University from (2005 to 2010) where I was a chief resident in 2010. My surgical oncology and head and neck training was performed at the Fox Chase Cancer Center in Philadelphia from 2010 to 2012. At the same time I underwent a masters in science (Clinical research for health professionals) at the University of Drexel. Through the International Federation of Head and Neck Societies / Memorial Sloan Kettering Cancer Center I performed a two year head and neck surgery and oncology / endocrine fellowship that ended in 2016. Mi nombre es Rodrigo Arrangoiz, soy cirujano oncólogo / cirujano de tumores de cabeza y cuello / cirujano endocrino que trabaja Center for Advanced Surgical Oncology en Miami, Florida. Fui entrenado como cirujano en Michigan State University (2005 a 2010 ) donde fui jefe de residentes en 2010. Mi formación en oncología quirúrgica y e n tumores de cabeza y cuello se realizó en el Fox Chase Cancer Center en Filadelfia de 2010 a 2012. Al mismo tiempo, me sometí a una maestría en ciencias (investigación clínica para profesionales de la salud) en la Universidad de Drexel. A través de la Federación Internacional de Sociedades de Cabeza y Cuello / Memorial Sloan Kettering Cancer Center realicé una sub especialidad en cirugía de cabeza y cuello / cirugia endocrina de dos años que terminó en 2016.

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