Papillary Thyroid Cancer with Focal Tall-Cell Changes Have Similar Disease Characteristics and Outcomes as Tall-Cell Variants of Papillary Thyroid Cancer

Rodrigo Arrangoiz MS, MD, FACS, FSSO

Presentation1

  • Despite the excellent outcomes for most patients with papillary thyroid carcinoma (PTC), some histologic variants demonstrate more aggressive behavior, as defined by:
    • Higher rates of metastasis, recurrence, and resistance to treatment with radioactive iodine (RAI).
  • The tall-cell variant of PTC:
    • First reported in 1976
    • Is characterized by:
      • Cell height that is at least two to three times its width
      • Eosinophilic cytoplasm
      • Basal nuclei
      • Classic nuclear features of PTC
      • Higher prevalence of BRAF V600E mutations
    • There has been significant variability in its description, including the proportion of cells required to make the diagnosis of tall-cell PTC:
      • The 4th edition of the World Health Organization classification of endocrine tumors:
        • Revised the threshold value of tall-cell change as ≥30%

 

 

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Published by Rodrigo Arrangoiz MS, MD, FACS, FSSO

My name is Rodrigo Arrangoiz I am a breast surgeon/ thyroid surgeon / parathyroid surgeon / head and neck surgeon / surgical oncologist that works at Center for Advanced Surgical Oncology in Miami, Florida. I was trained as a surgeon at Michigan State University from (2005 to 2010) where I was a chief resident in 2010. My surgical oncology and head and neck training was performed at the Fox Chase Cancer Center in Philadelphia from 2010 to 2012. At the same time I underwent a masters in science (Clinical research for health professionals) at the University of Drexel. Through the International Federation of Head and Neck Societies / Memorial Sloan Kettering Cancer Center I performed a two year head and neck surgery and oncology / endocrine fellowship that ended in 2016. Mi nombre es Rodrigo Arrangoiz, soy cirujano oncólogo / cirujano de tumores de cabeza y cuello / cirujano endocrino que trabaja Center for Advanced Surgical Oncology en Miami, Florida. Fui entrenado como cirujano en Michigan State University (2005 a 2010 ) donde fui jefe de residentes en 2010. Mi formación en oncología quirúrgica y e n tumores de cabeza y cuello se realizó en el Fox Chase Cancer Center en Filadelfia de 2010 a 2012. Al mismo tiempo, me sometí a una maestría en ciencias (investigación clínica para profesionales de la salud) en la Universidad de Drexel. A través de la Federación Internacional de Sociedades de Cabeza y Cuello / Memorial Sloan Kettering Cancer Center realicé una sub especialidad en cirugía de cabeza y cuello / cirugia endocrina de dos años que terminó en 2016.

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