Accelerated Partial Breast Irradiation

• Accelerated partial breast irradiation includes multiple techniques such as:
  • Interstitial brachytherapy
  • Applicator brachytherapy
  • External beam radiation therapy.
• The Groupe Européen de Curiethérapie of European Society for Radiotherapy and Oncology (GEC-ESTRO) trial:
  • Randomized 1184 patients with:
    • Low-risk invasive carcinoma or ductal carcinoma in situ (DCIS) treated with breast-conserving surgery to either whole-breast irradiation (WBI) or APBI using multicatheter brachytherapy:
      • The cumulative incidence of local recurrence at 5 years was:
        • 1.44% with APBI
        • 0.92% with WBI
• The Florence trial;
  • Randomized 520 patients to either WBI or APBI with intensity-modulated radiation therapy:
    • With a mean follow-up of 5 years:
      • The rate of local recurrence was:
        • 1.5% in both arms
• The American Society of Breast Surgeons’ MammoSite Registry found:
  • 5-year rates of local recurrence were less than 4%.
• An older randomized trial from Hungary using interstitial APBI and electrons:
  • 5-year local recurrence rate of 4.7%.

• It is important to recognize that these outcomes are likely due to:
  • The highly selected, low-risk patient populations included in many of the APBI trials as evidenced by the tables / guidelines.
    • Patients tend to be:
      • Postmenopausal
      • Tumors less than 3 cm, without DCIS
      • Node negative
      • ER-positive

Table: ASTRO Consensus Guidelines for Accelerated Partial Breast Irradiation

Table: American Brachytherapy Society Guidelinesfor Accelerated Partial Breast Irradiation

Table: GEC-ESTRO Guidelines for Accelerated Partial Breast Irradiation

Table: American Society of Breast Surgeons Accelerated Partial Breast Irradiation Position Statement

Additional follow-up is necessary and ongoing

 

Rodrigo Arrangoiz MS, MD, FACS a surgical oncologist and is a member of Sociedad Quirúrgica S.C at the America British Cowdray Medical Center in Mexico City:

• He is an expert in the management of breast cancer.

  • If you have any questions about Partial Breast Irriadation  please fill free to contact Dr. Arrangoiz.

Training:

• General surgery:

• Michigan State University:

• 2004 al 2010

• Surgical Oncology / Head and Neck Surgery / Endocrine Surgery:

• Fox Chase Cancer Center (Filadelfia):

• 2010 al 2012

• Masters in Science (Clinical research for health professionals):

• Drexel University (Filadelfia):

• 2010 al 2012

• Surgical Oncology / Head and Neck Surgery / Endocrine Surgery:

• IFHNOS / Memorial Sloan Kettering Cancer Center:

• 2014 al 2016

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http://www.sociedadquirurigca.com