Histopathologic Determination of Parathyroid Carcinoma (PC)

Rodrigo Arrangoiz MS, MD, FACS, FSSO

The histopathologic determination of a PC versus a parathyroid adenoma can be demanding for the pathologist.

These tumors are mostly solitary and arise from a single gland; however, there have been reports of multi-glandular involvement. The right and left inferior parathyroid glands have been deemed as the most common sites for PC.

Ectopic tumors usually arise from parathyroid glands in the mediastinum, but ectopic locations do not increase the chance of malignant transformation of the gland. Synchronous PC and adenoma have been reported .

The classic histological criteria for parathyroid cancers was established by Schantz and Castleman:

  • They differentiated PC from parathyroid adenomas as a distinct entity and found that there was no evidence that PC originated from adenomas or hyperplasia of the parathyroid glands.
  • They described that PC are characterized by chief cells (which are usually the predominant cell type in the parathyroid glands) arranged in a trabecular, solid, or acinar pattern with the loss of the typical lobular pattern.

 

Rodrigo Arrangoiz MS, MD, FACS
Cirugía Oncológica
Fox Chase Cancer Center
Tumores de Cabeza y Cuello / Cirugía Endocrina
Fox Chase Cancer Center
Tumores de Cabeza y Cuello / Cirugía Endocrina
IFHNOS / Memorial Sloan Kettering Cancer Center
Maestría en Ciencias de Investigación
Drexel University
Certificado por el Colegio Americano de Cirugía
Fellow del Colegio Americano de Cirugía
Fellow de la Sociedad de Cirugia Oncológica 
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Published by Rodrigo Arrangoiz MS, MD, FACS, FSSO

My name is Rodrigo Arrangoiz I am a breast surgeon/ thyroid surgeon / parathyroid surgeon / head and neck surgeon / surgical oncologist that works at Center for Advanced Surgical Oncology in Miami, Florida. I was trained as a surgeon at Michigan State University from (2005 to 2010) where I was a chief resident in 2010. My surgical oncology and head and neck training was performed at the Fox Chase Cancer Center in Philadelphia from 2010 to 2012. At the same time I underwent a masters in science (Clinical research for health professionals) at the University of Drexel. Through the International Federation of Head and Neck Societies / Memorial Sloan Kettering Cancer Center I performed a two year head and neck surgery and oncology / endocrine fellowship that ended in 2016. Mi nombre es Rodrigo Arrangoiz, soy cirujano oncólogo / cirujano de tumores de cabeza y cuello / cirujano endocrino que trabaja Center for Advanced Surgical Oncology en Miami, Florida. Fui entrenado como cirujano en Michigan State University (2005 a 2010 ) donde fui jefe de residentes en 2010. Mi formación en oncología quirúrgica y e n tumores de cabeza y cuello se realizó en el Fox Chase Cancer Center en Filadelfia de 2010 a 2012. Al mismo tiempo, me sometí a una maestría en ciencias (investigación clínica para profesionales de la salud) en la Universidad de Drexel. A través de la Federación Internacional de Sociedades de Cabeza y Cuello / Memorial Sloan Kettering Cancer Center realicé una sub especialidad en cirugía de cabeza y cuello / cirugia endocrina de dos años que terminó en 2016.

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