• Calcitonin:
    • Is produced by the:
      • Parafollicular cells (C cells) / C-cells of the thyroid gland:
        • Works to oppose the actions of PTH
    • It helps lower ionized calcium levels in primarily two ways:
      • First, it inhibits osteoclast-mediated bone resorption
      • Second, it inhibits resorption of calcium and phosphate by the kidney
  • Calcitonin:
    • Has no direct effects on:
      • Intestinal absorption
      • Osteoblast-mediated bone formation
  • It is also used in the treatment of hypercalcemic crisis:
    • 4 IU/kg subcutaneously / intramuscularly
  • It acts quickly (24 to 48 hours):
    • Is more effective when used in combination with glucocorticoids
  • Finally, calcitonin is a useful marker:
    • With regard to surveillance in medullary thyroid carcinoma

#Arrangoiz #Calcitonin #ParathyroidSurgeon #ParathyroidExpert #CalciumHemostasis #Teacher #Surgeon #HeadandNeckSurgeon #CancerSurgeon #MSMC #MountSinaiMedicalCenter #Miami #Mexico

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