Hypercalcemia and Thiazide Diuretic Use

👉Elevated serum calcium levels have been associated with thiazide diuretic use and need to be differentiated from primary hyperparthyroidism – Dr. Rodrigo Arrangoiz

👉The overall annual age- and sex-adjusted (to 2000 U.S. whites) incidence of hypercalcemia due to thiazide diuretic use was 7.7 (95% CI, 5.9 to 9.5) per 100,000 individuals.

👉The average 24-hour plasma calcium concentrations are increased with thiazide diuretic use, but the mean 24-hour PTH levels remain unchanged in subjects with normal baseline PTH levels and no evidence of hypercalciuria.

👉Thiazides diuretics have several metabolic effects that may contribute to increased calcium levels:

  • A decrease in urine calcium excretion is the most likely cause.
  • In some cases of diuretic use metabolic alkalosis can occur that could cause an increase in total serum calcium levels through a pH-dependent increase in protein-bound calcium.
  • Although plasma 1,25 (OH) vitamin D levels are unchanged, increased intestinal calcium absorption in response to thiazide diurectic use has been noted and could also contribute to an increase in serum calcium.
  • One last possible explanation for the elevated serum calcium levels associated with thiazide diuretic use is hemoconcentration associated with diuresis.

👉CheckYourCalcium (realízate un calcio total en sangre).

#CheckYourCalcium #Arrangoiz #ParathyroidExpert #ParathyroidSurgeon #Hiperparatiroidism #Hipercalcemia #CheckYourCalcium #HeadandNeckSurgeon #MountSinaiMedicalCenter

👉 Para obtener más información sobre el hiperparatiroidismo: http://www.hiperparatiroidismo.info


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