- Primary Hyperparathyroidism (PHPT):
- Occurs when one (or more) of the four parathyroid glands grows into a tumor and behaves inappropriately by constantly making excess parathyroid hormone (PTH)
- The parathyroid glands grow into a tumor and produce too much parathyroid hormone (PTH):
- Which removes calcium from the bones
- In Primary Hyperparathyroidism (PHPT) the tumor (Adenoma):
- Has lost its control mechanism and makes large amounts of parathyroid hormone (PTH):
- Thus, even when the serum calcium level is high:
- When the normal response of the parathyroid glands should be to stop making any PTH at all:
- One of the parathyroid glands keeps making the parathyroid hormone
- When the normal response of the parathyroid glands should be to stop making any PTH at all:
- Thus, even when the serum calcium level is high:
- Has lost its control mechanism and makes large amounts of parathyroid hormone (PTH):
- One important thing to remember as you read about PHPT:
- Is that the abnormal PTH production is caused by a benign parathyroid tumor, called ADENOMA:
- It is not a cancer:
- However this disease (PHPT) can increase the occurrence of other cancers:
- Breast Cancer
- Prostate Cancer
- Renal Cancer
- Skin Cancer
- Colon and rectal cancer
- However this disease (PHPT) can increase the occurrence of other cancers:
- It is not a cancer:
- Is that the abnormal PTH production is caused by a benign parathyroid tumor, called ADENOMA:
- The most common cause of excess hormone production (primary hyperparathyroidism):
- Is the development of a benign tumor in one of the parathyroid glands:
- This enlargement of one parathyroid glands is called a:
- Parathyroid adenoma:
- Which accounts for roughly 85% to 90% of all patients with primary hyperparathyroidism:
- The other 10% to 15% will have more than one bad gland (mulitiglandular disease):
- Doble Adenomas:
- 6% to 9% of the cases
- Triple Adenomas:
- Less than 0.3% of the cases
- Parathyroid Gland Hyperplasia:
- 3% of the cases
- Doble Adenomas:
- The other 10% to 15% will have more than one bad gland (mulitiglandular disease):
- Which accounts for roughly 85% to 90% of all patients with primary hyperparathyroidism:
- Parathyroid adenoma:
- This enlargement of one parathyroid glands is called a:
- Is the development of a benign tumor in one of the parathyroid glands:
- This out of control (autonomously functioning) parathyroid gland:
- Is essentially never cancerous (virtually 99% of them are benign tumors):
- However, PHPT slowly causes damage to the body:
- Because it induces an abnormally high level of calcium in the blood:
- Which can slowly destroy a number of tissues
- Because it induces an abnormally high level of calcium in the blood:
- However, PHPT slowly causes damage to the body:
- Is essentially never cancerous (virtually 99% of them are benign tumors):
- Parathyroid adenomas:
- Typically are much bigger than the normal “grain-of-rice” parathyroid and will frequently be about the size of an olive or grape:
- Thus, the typical patient with primary hyperparathyroidism will be cured of the disease when this “grape” size tumor is removed
- Up to 30% will have more than one tumor
- This tumor / adenoma will almost always continue to grow until it is removed:
- As it grows, it makes more PTH and will make you feel worse (symptomatic)
- This tumor is constantly making parathyroid hormone (PTH):
- Which is what takes the calcium out of your bones and makes the calcium in your blood too high
- Typically are much bigger than the normal “grain-of-rice” parathyroid and will frequently be about the size of an olive or grape:

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