DCIS is a proliferation of malignant cells that have not breached the ductal basement membrane:
They arise from ductal epithelium:
In the region of the terminal ductal–lobular unit (TDLU)
DCIS had previously been considered one stage in the continuum of histologic progression from ADH to invasive carcinoma:
But, in fact, DCIS comprises a heterogeneous group of lesions:
With variable histologic architecture, molecular and cellular characteristics, and clinical behavior
Malignant cells proliferate:
Until the ductal lumen is obliterated
There may be associated breakdown of the myoepithelial celllayer of the basement membrane surrounding the ductal lumen
DCIS has also been linked with changes in the surrounding stroma resulting in:
Fibroblast proliferation
Lymphocyte infiltration
Angiogenesis
Thus, although the process is poorly understood:
Most but not all invasive ductal carcinomas are believed to arise from DCIS:
Which is considered a nonobligate precursor of invasive breast carcinoma
Architectural heterogeneity is a common feature of DCIS. Even in the same lesion, DCIS may show different growth patterns. Image is showing a cribriform DICSMicropapillary DCISPapillary DCISSolid DCIS
My name is Rodrigo Arrangoiz I am a breast surgeon/ thyroid surgeon / parathyroid surgeon / head and neck surgeon / surgical oncologist that works at Center for Advanced Surgical Oncology in Miami, Florida.
I was trained as a surgeon at Michigan State University from (2005 to 2010) where I was a chief resident in 2010. My surgical oncology and head and neck training was performed at the Fox Chase Cancer Center in Philadelphia from 2010 to 2012. At the same time I underwent a masters in science (Clinical research for health professionals) at the University of Drexel. Through the International Federation of Head and Neck Societies / Memorial Sloan Kettering Cancer Center I performed a two year head and neck surgery and oncology / endocrine fellowship that ended in 2016.
Mi nombre es Rodrigo Arrangoiz, soy cirujano oncólogo / cirujano de tumores de cabeza y cuello / cirujano endocrino que trabaja Center for Advanced Surgical Oncology en Miami, Florida.
Fui entrenado como cirujano en Michigan State University (2005 a 2010 ) donde fui jefe de residentes en 2010. Mi formación en oncología quirúrgica y e n tumores de cabeza y cuello se realizó en el Fox Chase Cancer Center en Filadelfia de 2010 a 2012. Al mismo tiempo, me sometí a una maestría en ciencias (investigación clínica para profesionales de la salud) en la Universidad de Drexel. A través de la Federación Internacional de Sociedades de Cabeza y Cuello / Memorial Sloan Kettering Cancer Center realicé una sub especialidad en cirugía de cabeza y cuello / cirugia endocrina de dos años que terminó en 2016.
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Rodrigo Arrangoiz MS, MD, FACS, FSSO 