Etiology of Hypothyroidism


  • Excluding thyroidectomy and radioactive iodine (131I) ablation:

    • The most common causes of hypothyroidism in the adult are:

      • Hashimoto’s thyroiditis

      • The hypothyroid phase of subacute thyroiditis

    • Because the long-term treatment is very different:

      • The clinicians must distinguish between these conditions.


  • The common causes of low circulating thyroid hormone levels are:

    • Primary hypothyroidism  (thyroid failure with elevated TSH):
      • Hashimoto’s thyroiditis (chronic lymphocytic thyroiditis)
      • Hypothyroid phase of painful subacute thyroiditis:
        • Pseudo-granulomatous–De Quervain’s
      • Hypothyroid phase of painless lymphocytic thyroiditis
      • Hypothyroid phase of postpartum thyroiditis
      • Radioactive iodine ablation
      • Thyroidectomy
      • Head and neck radiation
      • Drugs:
        • Lithium
        • Amiodarone
        • Interleukin
        • Interferon
        • Propylthiouracil / methimazole
        • Iodine excess in patients with thyroiditis
      • Iodine deficiency (uncommon in the United States)
      • Biosynthetic defects (rare and presents in childhood)
      • Congenital hypothyroidism (rare and presents in childhood)
    • Secondary (hypothyroidism with low or inappropriately normal TSH):
      • Pituitary dysfunction:
        • Pituitary damage from tumor, surgery, and / or radiation
    • Tertiary:
      • Hypothalamic damage from:
        • Tumor, and / or radiation

The causes of thyroid hypothyroidism. Infographics. Vector illustration on isolated background.symptoms-of-hypothryroidism

#HeadandNeckSurgeon #ThyroidExpert #SurgicalOncologist #EndocrineSurgery #MountSinaiMedicalCenter #Miami #ThyroidNodule #ToxicNodularGoiter #TNG #MultinodularGoiter #Hypothyroidism #Thyroiditis #Goiter

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